Griffin Joiner had four hits and drove in two runs as every Lady Colonel starter had at least one hit.
Maggie Glass hit a two-run home run in the first inning, and Hannah Hodge added a three-run pinch home run in the fifth for Christian County (4-0).
Kayla Wade, Carly P'Pool, Annie Coleman, and Casey Hayes each had two hits for the Lady Colonels.
Hannah Driver (above) picked up the win, allowing one hit in 2 2/3 innings and struck out five.
Hopkinsville (1-5) got singles from Brittany Castle, Mallory Smithson, and Callie Tackett.
Christian County will play in a tournament in Murfreesboro, Tennessee this weekend before traveling south to Alabama to play in a tourney there next week.
Hopkinsville will next play April 12 against University Heights.